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N1-Methylpseudouridine is a modified nucleoside used for enhancing mRNA translation. Incorporation of N1-Methylpseudouridine into mRNA turns off the immune/eIF2α phosphorylation-dependent inhibition of translation, and increases ribosome pausing and density on the mRNA, thus dramatically facilitating the translation process. N1-Methylpseudouridine outperforms several other modified nucleosides (e.g. 5-Methylcytidine) and corresponding combinations in terms of translation capacity. 


1. Svitkin YV, Cheng YM, Chakraborty T, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Research, 2017, 45(10): 6023-6036.

2. Andries O, Mc Cafferty S, De Smedt SC, et al N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. Journal of Controlled Release, 2015, 217: 337-344.

For research use only.


Technical Information

Formal Name: N1-Methyl-Pseudouridine
CAS Number: 13860-38-3
Molecular Formula: C10H14N2O6
Molecular Weight: 258.23
Purity: 99.5%
Appearance: White solid
Storage Condition: -20 ℃
Shipping Condition: Room temperature

To order

Buy Cat.No. Product name Size Price
LP013-1 N1-Methylpseudouridine 1 g $300
LP013-2 N1-Methylpseudouridine 5 g $1200
LP013-3 N1-Methylpseudouridine 10 g $2200


Product Information (PDF): LP013

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