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• Sep, 28, 2021
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Introduction To order Documents Related Products Introduction 5-Methyl-CTP (5-Methylcytidine-5'-Triphosphate) is a modified nucleoside triphosphate employed to impart desirable characteristics such as increased nuclease stability, increased translation or reduced interaction of innate immune receptors with in vitro transcribed RNA. 5-Methyl-CTP, as well as Pseudo-UTP and N1-Methylpseudo-UTP, have been shown to reduce innate immune stimulation in culture […]

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• Sep, 28, 2021
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Introduction To order Documents Related Products Introduction Pseudo-UTP (Pseudouridine-5'-Triphosphate) is one of the most commonly used modified nucleoside-5’-O-triphosphates. Pseudo-UTP is a building block for the polymerase-mediated synthesis of RNA molecules. RNA molecules, especially messenger RNAs (mRNAs), have widespread applications in therapeutic and diagnostic areas, and have demonstrated their superiority over plasmid DNA techniques in both […]

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• Sep, 28, 2021
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Introduction To order Documents Related Products Introduction N1-Methylpseudo-UTP (N1-Methyl-Pseudouridine-5'-Triphosphate) is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-methylpseudouridine can reduce the immunogenicity of the resulting mRNA. It was reported that N1-methylpseudouridine (m1Ψ) modification alone or in combination with 5-methylcytidine (m5C) exhibited superiority over the current state-of-the-art pseudouridine […]

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• Jul, 14, 2021
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Introduction To Order Related Products Introduction Lipid Nanoparticles (LNPs) play important role for delivery of mRNA-based vaccines. ABP Biosciences offers a list of key lipids for formulation of Lipid Nanoparticles (LNPs).   Lipid   Role SM-102   Ionizable amino lipid ALC-0315   Ionizable amino lipid ALC-0159   Coating Lipid DMG-PEG2000   Coating Lipid DSPC   Structural/Helper […]

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• Jul, 14, 2021
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Introduction To order Documents Related Products Introduction LNP-0315 is a lipid nanoparticle (LNP) formulated with ALC-0315, DSPC, Cholesterol, and ALC-0159.  LNP-0315 is formulated at optimal molar ratio for efficient delivery of mRNA-based vaccines. LNP-0315 is supplied at 10 mg/mL stock solution in ethanol. For research use only.   To order Buy Cat.No. Product name Size Price LP008-1 LNP-0315 1 mL […]

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• Jul, 14, 2021
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Introduction To order Documents Related Products Introduction LNP-102 is a lipid nanoparticle (LNP) formulated with SM-102, DSPC, Cholesterol, and DMG-PEG2000.  LNP-102 is formulated at optimal molar ratio for efficient delivery of mRNA-based vaccines. LNP-102 is supplied at 10 mg/mL stock solution in ethanol. For research use only.   To order Buy Cat.No. Product name Size Price LP007-1 LNP-102 1 […]

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• Jul, 14, 2021
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Introduction To order Documents Related Products Introduction 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral phospholipid containing 18:1 fatty acids at the sn–1 and sn–2 positions. The compound displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH. DOPE can be used as an emulsifier to facilitate DNA-liposome complex […]

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• Jul, 14, 2021
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Introduction To order Documents Related Products Introduction 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (DSPC) is a phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn–1 and sn–2 positions. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Formulations containing DSPC have been used in the development of lipid nanoparticles for the delivery of […]

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• Jul, 14, 2021
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Introduction To order Documents Related Products Introduction DMG-PEG(2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Formulations containing DMG-PEG(2000) have been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines. For research use only.     Technical Information   Formal […]

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• Jul, 14, 2021
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Introduction To order Documents Related Products Introduction ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons. It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine that contains the active ingredient tozinameran. For research use only.     Technical Information   Formal Name: […]