Recombinant Human Angiotensin-Converting Enzyme 2/ACE-2 protein produced by transfected human cells is a secreted protein with sequence (Ser19-Asp615) of human ACE-2.
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
A DNA sequence encoding the human ACE2 Protein (Ser19-Asp615) was expressed.
> 95% as determined by SDS-PAGE.
< 1.0 EU per μg protein as determined by the LAL method.
Predicted N Terminal:
The recombinant human ACE2 Protein consists of 597 amino acids and predicts a molecular mass of 69.1 kDa.
Protein Storage Buffer:
150 mM NaCl, 20 mM NaHCO3, pH 7.0.
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