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Recombinant Human ACE2 Protein (Fc Tag)


Recombinant Human ACE2 protein (Fc Tag) was expressed with the Fc region of human IgG1 at the C-terminus.

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.

Protein Construction:

A DNA sequence encoding the human ACE2 Protein (Ser19-Asp615) was expressed with the Fc region of human IgG1 at the C-terminus.



Expressed Host:

HEK293 Cells.


> 95% as determined by SDS-PAGE.


< 1.0 EU per μg protein as determined by the LAL method.

Predicted N Terminal:


Molecule Weight:

The recombinant human ACE2 (Fc Tag) Protein consists of 842 amino acids and predicts a molecular mass of 96.5 kDa.

Protein Storage Buffer:

150 mM NaCl, 20 mM NaHCO3, pH 7.0.




1. Koitka A, et al. (2008) Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol. 35(4): 420-5.

2. Raizada MK, et al. (2007) ACE2: a new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50(2): 112-9.

3. Imai Y, et al. (2007) Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3): 405-10.


To Order

Buy Cat. No. Product Name Unit Price
P104 Recombinant Human ACE2 Protein (Fc Tag) 50 µg $400


Protocol (PDF): P104