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Andy Fluor™ 555 DBCO

Introduction

Click chemistry describes a class of chemical reactions that use bio-orthogonal or biologically unique moieties to label and detect a molecule of interest in mild, aqueous conditions. DBCO alkynes can be used to perform click reactions with azide-modified targets without the use of heavy metal catalysis. DBCO reactions are ideal for surface labeling of live cells and also minimize damage to fluorescent proteins like GFP or R-PE.
The Andy Fluor™ 555 DBCO is reactive with azide via a Strain-promoted Azide-Alkyne Click Chemistry reaction (SPAAC).
 

Features

  • Efficiency—the click reaction is complete in less than 1 hour;
  • Specificity—the reaction between the label and detection tag is selective and specific;
  • Stability—the reaction product contains an irreversible, covalent bond;
  • Biologically inert—the components of the reaction do not undergo any side reactions.

 

Figure 1. Click chemistry labeling


Specifications

Label: Andy Fluor™ 555
Ex/Em: 553/565
Detection Method: Fluorescent
Solubility: DMSO, DMF
Product Size: 0.5 µmol
Storage Conditions: -20 ℃, protect from light
Shipping Condition: Room Temperature

Applications
Click chemistry labeling

 

To order

Buy Cat.No. Product Name Ex/Em(nm) Unit Price
C332 Andy Fluor™ 555 DBCO 553/565 0.5 µmol $275
 

Documents

Datasheet (PDF): C332
MSDS (PDF): C332

Reference

Click-mediated labeling of bacterial membranes through metabolic modification of the lipopolysaccharide inner core.
Dumont A, Malleron A, Awwad M, Dukan S, Vauzeilles B,
Angew Chem Int Ed Engl (2012) 51:3143-3146

Winz ML, Samanta A, Benzinger D, Jäschke A,
Nucleic Acids Res (2012) 40:e78-e78