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Coelenterazine

Introduction

Coelenterazine is a bioluminescence probe for measuring Ca2+ concentration in cells with a high sensitivity and large dynamic range. Coelenterazine (native form) is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. The aequorin complex has been used as an excellent calcium indicator that can measure a broad concentration range of calcium from ~0.1 mM to >100 mM. Luminophore of the aequorin complex which is oxidized by oxygen to illuminate at 465 nm when Ca2+ binds to the complex.
 

Specifications

Label:
Em: 465 nm
Detection Method: Bioluminescent
Solubility: methanol, ethanol
Molecular Formula: C26H21N3O3
Molecular Weight: 423.47
CAS Number: 55779-48-1
Storage Conditions: -20 ℃, protect from light
Shipping Condition: Room Temperature

Applications
Calcium indicator

To order

Buy Cat.No. Product name Ex/Em(nm) Size Price
C238 Coelenterazine   1 mg $150

Documents

Datasheet (PDF): C238
MSDS (PDF): MSDS-C238

References:

Expression of apo-aequorin during embryonic development; how much is needed for calcium imaging?
Créton R, Steele ME, Jaffe LF
Cell Calcium (1997) 22:439-446

 

A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway.
Wunder F, Stasch JP, Hütter J, Alonso-Alija C, Hüser J, Lohrmann E
Anal Biochem (2005) 339:104-112

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